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KMID : 0848020020050040291
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Journal of Korean Breast Cancer Society
2002 Volume.5 No. 4 p.291 ~ p.297
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Significance of the Expression of p27Kip1 Protein in Human Breast Cancer
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김찬용/Kim CY
양근호/배병노/김기환/김홍주/김영덕/김홍용/박경미/한세환/Yang KH/Bae BN/Kim KH/Kim HJ/Kim YD/Kim HY/Park KM/Han SH
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Abstract
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Purpose : p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. It binds to a variety of cyclin/CDK complexes, inhibits kinase activity and blocks the cell cycle as a negative regulator. Reduced p27Kip1 expression has been reported to be a significant predictor of poor survival in numerous human breast cancers. We executed p27Kip1 protein assay in primary breast cancer and compared these result with known prognostic parameters.
Methods : Immunohistochemical assay was performed on tissue microarrays from 183 patients with breast cancer to evaluate the biologic and clinical significance of p27Kip1 expression.
Results : Decreased p27Kip1 expression was significantly associated with clinical stage (P=0.027), low nuclear grade (P<0.001), high histologic grade (P<0.001), high score mitotic index (P<0.001), increased Ki67 labeled index (P=0.006) and negative estrogen receptor status (P=0.0024). In survival analysis, p27Kip1 was useful to predict diseasefree survival (P=0.0106) and overall survival (P=0.0154) of the patient after surgery followed by chemotherapy or radiation therapy.
Conclusion : Reduced expression of p27Kip1 protein was associated with biologically aggressive phenotype of breast cancer and was an useful to predict patient outcome.
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KEYWORD
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